Late-stage C–H functionalization of azines
CM Josephitis, HMH Nguyen, A McNally - Chemical reviews, 2023 - ACS Publications
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …
Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review
N-heterocycles are important, not only because of their abundance, but above all because of
their chemical, biological and technical significance. They play an important role in …
their chemical, biological and technical significance. They play an important role in …
Transition metals-catalyzed amination of biomass feedstocks for sustainable construction of N-heterocycles
Q Yan, X Wu, H Jiang, H Wang, F Xu, H Li… - Coordination Chemistry …, 2024 - Elsevier
Transition metals, which are of diversity in their bonding orbitals, have a variety of significant
oxidation states and more complex chemical properties compared to the main group metals …
oxidation states and more complex chemical properties compared to the main group metals …
Radical hydrocarboxylation of unactivated alkenes via photocatalytic formate activation
SN Alektiar, J Han, Y Dang, CZ Rubel… - Journal of the …, 2023 - ACS Publications
Herein we disclose a strategy to promote the hydrocarboxylation of unactivated alkenes
using photochemical activation of formate salts. We illustrate that an alternative initiation …
using photochemical activation of formate salts. We illustrate that an alternative initiation …
Recent strategies in the nucleophilic dearomatization of pyridines, quinolines, and isoquinolines
M Escolano, D Gaviña, G Alzuet-Piña… - Chemical …, 2024 - ACS Publications
Dearomatization reactions have become fundamental chemical transformations in organic
synthesis since they allow for the generation of three-dimensional complexity from two …
synthesis since they allow for the generation of three-dimensional complexity from two …
C3-selective trifluoromethylthiolation and difluoromethylthiolation of pyridines and pyridine drugs via dihydropyridine intermediates
XY Zhou, M Zhang, Z Liu, JH He… - Journal of the American …, 2022 - ACS Publications
Herein, we report a method for C3-selective C–H tri-and difluoromethylthiolation of
pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of …
pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of …
Photoinduced hydrocarboxylation via thiol-catalyzed delivery of formate across activated alkenes
SN Alektiar, ZK Wickens - Journal of the American Chemical …, 2021 - ACS Publications
Herein we disclose a new photochemical process to prepare carboxylic acids from formate
salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across …
salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across …
Selective three-component reductive alkylalkenylation of unbiased alkenes via carbonyl-directed nickel catalysis
F Wang, S Pan, S Zhu, L Chu - ACS Catalysis, 2022 - ACS Publications
A Ni-catalyzed enantioselective reductive three-component alkylalkenylation of β, γ-alkenyl
ketones with cis-alkenyl iodides and fluoroalkyl iodides in the presence of Mn is reported. By …
ketones with cis-alkenyl iodides and fluoroalkyl iodides in the presence of Mn is reported. By …
Enantioselective C2–H alkylation of pyridines with 1, 3-dienes via Ni–Al bimetallic catalysis
JF Li, D Pan, HR Wang, T Zhang, Y Li… - Journal of the …, 2022 - ACS Publications
A chiral phosphine oxide-ligated Ni–Al bimetallic catalyst was used to realize an
enantioselective C2–H alkylation of pyridines without the need of a C2-block. A wide range …
enantioselective C2–H alkylation of pyridines without the need of a C2-block. A wide range …
A Self‐Reporting Fluorescent Salicylaldehyde–Chlorambucil Conjugate as a Type‐II ICD Inducer for Cancer Vaccines
M Zhang, X Jin, M Gao, Y Zhang… - Advanced Materials, 2022 - Wiley Online Library
Immunogenic cell death (ICD) can activate the anticancer immune response and is highly
attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic …
attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic …