Abstract Treatment of muscle invasive urothelial bladder carcinoma (BCa) remains a major
challenge. Comprehensive genomic profiling of tumors and identification of driver mutations …

Cancer is a devastating disease that has plagued humans from ancient times to this day.
After decades of slow research progress, promising drug development, and the identification …

Urothelial carcinoma of the bladder is the most frequent tumor of the urinary tract and
represents the fifth cause of death by cancer worldwide. The current first line chemotherapy …

Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-
glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β …

Background As the demand and application of engineered nanomaterials have increased,
their potential toxicity to the central nervous system has drawn increasing attention …

Discovery of transmission blocking compounds is an important intervention strategy
necessary to eliminate and eradicate malaria. To date only a small number of drugs that …

An accumulating understanding of the complex pathogenesis of acute myeloid leukemia
(AML) continues to lead to promising therapeutic approaches. Among the key aberrant …

Abstract Background/Aims: The alkylphospholipid perifosine is used for the treatment of
malignancy. The substance is effective by triggering suicidal tumor cell death or apoptosis …

The existence of cancer stem cells has been well established in acute myeloid leukemia.
Initial proof of the existence of leukemia stem cells (LSCs) was accomplished by functional …

Background Oncogenic roles of epidermal growth factor receptor pathway substrate no. 8
(EPS8) have been widely reported in various tumors, making targeting of EPS8 an …