Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
Cellular plasticity, reprogramming, and regeneration: metaplasia in the stomach and beyond
JR Goldenring, JC Mills - Gastroenterology, 2022 - Elsevier
The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …
Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis
H Takada, Y Sasagawa, M Yoshimura… - Nature …, 2023 - nature.com
Defects in gastric progenitor cell differentiation are associated with various gastric disorders,
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …
Regenerative proliferation of differentiated cells by mTORC 1‐dependent paligenosis
In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state …
changes governed the reversion of differentiated cells to a proliferative, regenerative state …
Pathogenesis and cells of origin of Barrett's esophagus
In patients with Barrett's esophagus (BE), metaplastic columnar mucosa containing epithelial
cells with gastric and intestinal features replaces esophageal squamous mucosa damaged …
cells with gastric and intestinal features replaces esophageal squamous mucosa damaged …
Pernicious anemia: the hematological presentation of a multifaceted disorder caused by cobalamin deficiency
G Esposito, L Dottori, G Pivetta, I Ligato, E Dilaghi… - Nutrients, 2022 - mdpi.com
Pernicious anemia is still a neglected disorder in many medical contexts and is
underdiagnosed in many patients. Pernicious anemia is linked to but different from …
underdiagnosed in many patients. Pernicious anemia is linked to but different from …
Bacterial chemotaxis in human diseases
B Zhou, CM Szymanski, A Baylink - Trends in Microbiology, 2023 - cell.com
To infect and cause disease, bacterial pathogens must localize to specific regions of the host
where they possess the metabolic and defensive acumen for survival. Motile flagellated …
where they possess the metabolic and defensive acumen for survival. Motile flagellated …
Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury
Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …
Gastritis: The clinico-pathological spectrum
The inflammatory spectrum of gastric diseases includes different clinico-pathological
entities, the etiology of which was recently established in the international Kyoto …
entities, the etiology of which was recently established in the international Kyoto …
Defining the identity and dynamics of adult gastric isthmus stem cells
The gastric corpus epithelium is the thickest part of the gastrointestinal tract and is rapidly
turned over. Several markers have been proposed for gastric corpus stem cells in both …
turned over. Several markers have been proposed for gastric corpus stem cells in both …