Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU Jin - Seminars in cancer biology, 2022 - Elsevier
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Cellular plasticity, reprogramming, and regeneration: metaplasia in the stomach and beyond

JR Goldenring, JC Mills - Gastroenterology, 2022 - Elsevier
The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

H Takada, Y Sasagawa, M Yoshimura… - Nature …, 2023 - nature.com
Defects in gastric progenitor cell differentiation are associated with various gastric disorders,
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …

Regenerative proliferation of differentiated cells by mTORC 1‐dependent paligenosis

SG Willet, MA Lewis, ZF Miao, D Liu, MD Radyk… - The EMBO …, 2018 - embopress.org
In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state …

Pathogenesis and cells of origin of Barrett's esophagus

J Que, KS Garman, RF Souza, SJ Spechler - Gastroenterology, 2019 - Elsevier
In patients with Barrett's esophagus (BE), metaplastic columnar mucosa containing epithelial
cells with gastric and intestinal features replaces esophageal squamous mucosa damaged …

Pernicious anemia: the hematological presentation of a multifaceted disorder caused by cobalamin deficiency

G Esposito, L Dottori, G Pivetta, I Ligato, E Dilaghi… - Nutrients, 2022 - mdpi.com
Pernicious anemia is still a neglected disorder in many medical contexts and is
underdiagnosed in many patients. Pernicious anemia is linked to but different from …

Bacterial chemotaxis in human diseases

B Zhou, CM Szymanski, A Baylink - Trends in Microbiology, 2023 - cell.com
To infect and cause disease, bacterial pathogens must localize to specific regions of the host
where they possess the metabolic and defensive acumen for survival. Motile flagellated …

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury

Z Ma, NK Lytle, B Chen, N Jyotsana, SW Novak… - Gastroenterology, 2022 - Elsevier
Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …

Gastritis: The clinico-pathological spectrum

M Rugge, E Savarino, M Sbaraglia, L Bricca… - Digestive and Liver …, 2021 - Elsevier
The inflammatory spectrum of gastric diseases includes different clinico-pathological
entities, the etiology of which was recently established in the international Kyoto …

Defining the identity and dynamics of adult gastric isthmus stem cells

S Han, J Fink, DJ Jörg, E Lee, MK Yum, L Chatzeli… - Cell stem cell, 2019 - cell.com
The gastric corpus epithelium is the thickest part of the gastrointestinal tract and is rapidly
turned over. Several markers have been proposed for gastric corpus stem cells in both …