Cellular and molecular effects of the mTOR inhibitor everolimus
mTOR (mechanistic target of rapamycin) functions as the central regulator for cell
proliferation, growth and survival. Up-regulation of proteins regulating mTOR, as well as its …
proliferation, growth and survival. Up-regulation of proteins regulating mTOR, as well as its …
[HTML][HTML] Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo
Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-
amplifying progenitors that differentiate in response to retinoic acid (RA) before entering …
amplifying progenitors that differentiate in response to retinoic acid (RA) before entering …
[HTML][HTML] The prognostic role of mTOR and p-mTOR for survival in non-small cell lung cancer: a systematic review and meta-analysis
L Li, D Liu, ZX Qiu, S Zhao, L Zhang, WM Li - PLoS One, 2015 - journals.plos.org
Objectives The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-
mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung …
mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung …
[HTML][HTML] Rapamycin, an mTOR inhibitor, induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell
YD Wang, YJ Su, JY Li, XC Yao… - International journal of …, 2015 - ncbi.nlm.nih.gov
Rapamycin is helpful in the treatment of certain cancers by inhibiting mTOR (mammalian
target of rapamycin) pathway. Here, rapamycin mediated apoptosis were investigated in …
target of rapamycin) pathway. Here, rapamycin mediated apoptosis were investigated in …
[HTML][HTML] Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1
YD Wang, YJ Su, JY Li, XC Yao… - International Journal of …, 2015 - ncbi.nlm.nih.gov
Rapamycin is useful in the treatment of certain cancers by inhibiting mTOR (mammalian
target of rapamycin) pathway. Here, anticancer activity and its acting mechanisms of …
target of rapamycin) pathway. Here, anticancer activity and its acting mechanisms of …
Comparative effectiveness of everolimus-based therapy versus endocrine monotherapy among postmenopausal women with HR+/HER2− metastatic breast cancer: a …
J Xie, Y Hao, N Li, PL Lin, E Ohashi, V Koo… - Current Medical …, 2015 - Taylor & Francis
Background: Everolimus-based therapy and endocrine monotherapy are used among
postmenopausal women with hormone receptor-positive human epidermal growth factor …
postmenopausal women with hormone receptor-positive human epidermal growth factor …
二甲双胍抑制人食管鳞癌KYSE450 细胞的增殖
丁显飞， 王峰， 刘凤云， 李砺锋， 郭丽娜， 周学良… - 肿瘤, 2016 - cqvip.com
目的: 探讨二甲双胍对人食管鳞癌KYSE450 细胞增殖的抑制作用及可能的作用机制. 方法:
常规培养人食管癌KYSE450 细胞, 经不同浓度的二甲双胍(5, 10, 20 和40 mmol/L) 处理后, MTT …
常规培养人食管癌KYSE450 细胞, 经不同浓度的二甲双胍(5, 10, 20 和40 mmol/L) 处理后, MTT …
Discovery of Novel Mammalian target of rapamycin (mTOR) Inhibitors by Support Vector Machine
P Wang, X Xu, Y Li, B Li, Q Pei, P Yu… - IOP Conference Series …, 2021 - iopscience.iop.org
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase playing the
central downstream role in multiple mitogenic signalling pathways. As ac entral regulator of …
central downstream role in multiple mitogenic signalling pathways. As ac entral regulator of …
雷帕霉素增加耐药胃癌细胞对多柔比星的敏感性
张正宝， 傅双， 王丽君 - 江苏医药, 2016 - cqvip.com
目的探讨雷帕霉素对耐药胃癌细胞对多柔比星敏感性的影响. 方法用含低浓度(0.5 μmol/L)
多柔比星培养基培养并建立耐药胃癌细胞株MKN45-R 和SNU1-R, 以不同浓度的多柔比星处理 …
多柔比星培养基培养并建立耐药胃癌细胞株MKN45-R 和SNU1-R, 以不同浓度的多柔比星处理 …
p70 核糖体蛋白S6 激酶抑制剂的研究进展
涂志军， 胡高云， 李乾斌 - 药学学报, 2015 - cqvip.com
p70 核糖体蛋白S6 激酶(p70 ribosomal protein S6 kinase, p70S6K) 是一种多功能的丝氨酸/苏
氨酸蛋白激酶, 是AGC 家族的重要成员, 在m TOR 信号通路中起着非常重要的作用. p70S6K …
氨酸蛋白激酶, 是AGC 家族的重要成员, 在m TOR 信号通路中起着非常重要的作用. p70S6K …