The early (intrauterine and neonatal) life environment plays an important role in
programming the susceptibility in later life to chronic degenerative diseases, such as …

Preterm infants have low circulating levels of leptin, a key trophic hormone that influences
growth and development. While the clinical importance of prematurity-associated leptin …

Background: It has been shown that leptin is present in breast milk and human mammary
epithelial cells are able to synthesize leptin. It has been suggested that leptin in human milk …

This study aimed to gain new insights into both systemic and placental leptin and its
receptors, with reference to the maternal prepregnancy body mass index (BMI). Thus, 84 …

Evidence is accumulating that the risk of osteoporosis in later life may be determined in part
by environmental influences on bone development during intrauterine and early postnatal …

OBJECTIVES: To investigate whether administration of leptin to rats during pregnancy and
lactation affects placental 11β-hydroxysteroid dehydrogenase (11β-HSD2) activity and the …

Objective Besides foetal or maternal disorders, placental dysfunction is a major cause of
intrauterine growth restriction (IUGR). Although numerous macro‐and histopathological …

Objective: To investigate the association between the leptin, leptin receptor and hormone
levels and hyperemesis gravidarum, and to determine whether these two parameters may …

There is clear evidence of placental leptin production, as shown recently in trophoblast
cultures and by dual in vitro placenta perfusion (median production of 225 pg/min per g of …

The contribution of placental leptin, if any, to both the fetal and maternal circulation and its
role in pregnancy remains to be determined. In an experiment to investigate this, 27 …