Alcohol use disorder, neurodegeneration, Alzheimer's and Parkinson's disease: Interplay between oxidative stress, neuroimmune response and excitotoxicity
Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as
Alzheimer's and Parkinson's disease. Prolonged excessive alcohol intake contributes to …
Alzheimer's and Parkinson's disease. Prolonged excessive alcohol intake contributes to …
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function
Many studies have reported that alcohol produces harmful effects on several brain
structures, including the hippocampus, in both rodents and humans. The hippocampus is …
structures, including the hippocampus, in both rodents and humans. The hippocampus is …
Ethanol, TLR 3, and TLR 4 Agonists Have Unique Innate Immune Responses in Neuron‐Like SH‐SY 5Y and Microglia‐Like BV 2
CJ Lawrimore, FT Crews - Alcoholism: Clinical and …, 2017 - Wiley Online Library
Background Ethanol (EtOH) consumption leads to an increase of proinflammatory signaling
via activation of Toll‐like receptors (TLR s) such as TLR 3 and TLR 4 that leads to kinase …
via activation of Toll‐like receptors (TLR s) such as TLR 3 and TLR 4 that leads to kinase …
Animal models of binge drinking, current challenges to improve face validity
Abstract Binge drinking (BD), ie, consuming a large amount of alcohol in a short period of
time, is an increasing public health issue. Though no clear definition has been adopted …
time, is an increasing public health issue. Though no clear definition has been adopted …
Drink and think: impact of alcohol on cognitive functions and dementia–evidence of dose-related effects
S Gutwinski, S Schreiter, J Priller, J Henssler… - …, 2018 - thieme-connect.com
Regular alcohol consumption affects cognitive performance and the development of
dementia. So far, findings are contradicting, which might be explained in part by dose …
dementia. So far, findings are contradicting, which might be explained in part by dose …
Ethanol exposure induces microglia activation and neuroinflammation through TLR4 activation and SENP6 modulation in the adolescent rat hippocampus
The ethanol‐induced toll‐like receptor 4 (TLR4) signal activation of microglia and
neuroinflammation are observed in both adolescent and adult rat brains, but the regulatory …
neuroinflammation are observed in both adolescent and adult rat brains, but the regulatory …
Adolescent intermittent alcohol exposure: dysregulation of thrombospondins and synapse formation are associated with decreased neuronal density in the adult …
Background Adolescent intermittent alcohol exposure (AIE) has profound effects on
neuronal function. We have previously shown that AIE causes aberrant hippocampal …
neuronal function. We have previously shown that AIE causes aberrant hippocampal …
Intermittent-excessive and chronic-moderate ethanol intake during adolescence impair spatial learning, memory and cognitive flexibility in the adulthood
Intermittent and excessive ethanol consumption over very short periods of time, known as
binge drinking, is common in the adolescence, considered a vulnerable period to the effects …
binge drinking, is common in the adolescence, considered a vulnerable period to the effects …
Timing eclipses amount: the critical importance of intermittency in alcohol exposure effects
LP Spear - Alcoholism: Clinical and Experimental Research, 2020 - Wiley Online Library
Frequency and duration of ethanol (EtOH) exposures influence the consequences of those
experiences, with evidence building from basic science studies in rats and mice that …
experiences, with evidence building from basic science studies in rats and mice that …
Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse
CE Van Skike, SE Maggio, AR Reynolds… - Progress in Neuro …, 2016 - Elsevier
Polysubstance abuse of alcohol and nicotine has been overlooked in our understanding of
the neurobiology of addiction and especially in the development of novel therapeutics for its …
the neurobiology of addiction and especially in the development of novel therapeutics for its …