Mismatch repair
The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
DNA mismatch repair
TA Kunkel, DA Erie - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects
mismatches generated during DNA replication and escape proofreading. MMR proteins also …
mismatches generated during DNA replication and escape proofreading. MMR proteins also …
Emergence and spread of antibiotic resistance following exposure to antibiotics
R Cantón, MI Morosini - FEMS microbiology reviews, 2011 - academic.oup.com
Within a susceptible wild-type population, a small fraction of cells, even< 10− 9, is not
affected when challenged by an antimicrobial agent. This subpopulation has mutations that …
affected when challenged by an antimicrobial agent. This subpopulation has mutations that …
Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance in Pseudomonas aeruginosa Strains Causing Chronic Lung Infections
MD Maciá, D Blanquer, B Togores… - Antimicrobial agents …, 2005 - Am Soc Microbiol
Pseudomonas aeruginosa is the most relevant pathogen producing chronic lung infections
in patients with chronic underlying diseases such as cystic fibrosis (CF), bronchiectasis, and …
in patients with chronic underlying diseases such as cystic fibrosis (CF), bronchiectasis, and …
In Vivo Evidence of Pseudomonas aeruginosa Nutrient Acquisition and Pathogenesis in the Lungs of Cystic Fibrosis Patients
MS Son, WJ Matthews Jr, Y Kang… - Infection and …, 2007 - Am Soc Microbiol
One of the hallmarks of Pseudomonas aeruginosa infection in cystic fibrosis (CF) patients is
very-high-cell-density (HCD) replication in the lung, allowing this bacterium to induce …
very-high-cell-density (HCD) replication in the lung, allowing this bacterium to induce …
Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in …
O Ciofu, LF Mandsberg, T Bjarnsholt… - …, 2010 - microbiologyresearch.org
During the chronic lung infection of patients with cystic fibrosis (CF), Pseudomonas
aeruginosa can survive for long periods due to adaptive evolution mediated by genetic …
aeruginosa can survive for long periods due to adaptive evolution mediated by genetic …
Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections
The advent of high-throughput sequencing techniques has made it possible to follow the
genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria …
genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria …
Role of small colony variants in persistence of Pseudomonas aeruginosa infections in cystic fibrosis lungs
JG Malone - Infection and drug resistance, 2015 - Taylor & Francis
Pseudomonas aeruginosa is an opportunistic pathogen that predominates during the later
stages of cystic fibrosis (CF) lung infections. Over many years of chronic lung colonization, P …
stages of cystic fibrosis (CF) lung infections. Over many years of chronic lung colonization, P …
Improvements on colony morphology identification towards bacterial profiling
Colony morphology may be an indicator of phenotypic variation, this being an important
adaptive process adopted by bacteria to overcome environmental stressors. Furthermore …
adaptive process adopted by bacteria to overcome environmental stressors. Furthermore …
Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection
Small colony variant (SCV) bacteria arise spontaneously within apparently homogeneous
microbial populations, largely in response to environmental stresses, such as antimicrobial …
microbial populations, largely in response to environmental stresses, such as antimicrobial …