• Introduction• The metastatic process‐Metastatic inefficiency‐Organ‐specific metastasis:
seed and soil‐Epithelial‐mesenchymal transition (EMT)• The cancer stem cell hypothesis …

Oxidative stress (OS) has been characterized by an imbalance between the production of
reactive oxygen species (ROS) and a biological system's ability to repair oxidative damage …

Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in
patients with acute promyelocytic leukemia (APL). There is limited long-term outcome data …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

Retinoids are essential for the maintenance of epithelial differentiation. As such, they play a
fundamental role in chemoprevention of epithelial carcinogenesis and in differentiation …

Acute promyelocytic leukaemia (APL) exhibits a characteristic t (15; 17) translocation that
fuses the promyelocytic leukaemia (PML) gene on 15q22 to the retinoic acid receptor α …

Fourteen patients with PML/RAR-positive acute promyelocytic leukemia (APL) were given
salvage therapy at the time of first molecular relapse. All patients had achieved first …

The curability of acute myeloid leukaemia (AML) in a fraction of adult patients was
demonstrated a long time ago. Currently, the probability of cure is consistently above fifty per …

To evaluate the prognostic impact of acute myeloid leukemia (AML) classifications,
specimens from 300 patients with 20% or more bone marrow myeloblast cells were studied …

Acute promyelocytic leukemia (APL) has become a curable disease by all-trans retinoic acid
(ATRA)-based induction therapy followed by two or three courses of consolidation …