Publisher Summary Directed evolution uses a combination of powerful search techniques to
generate proteins with the improved properties. The chapter focuses on controlling the …

We study self-replicating molecules under externally varying conditions. Changing
conditions such as temperature variations and/or alterations in the environment's resource …

This review is an introduction to theoretical models and mathematical calculations for
biological evolution, aimed at physicists. The methods in the field are naturally very similar to …

A strain-dependent random landscape model shows that many aspects of the mechanical
response of disordered materials are universal, and arise from the rugged nature of the …

Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic
fitness landscapes that aim to capture generic features of epistatic interactions in multilocus …

In this work, discrete dynamic optimization problems (DOPs) are theoretically analysed
according to the modifications produced in the fitness landscape during the optimization …

We investigate the evolutionary dynamics of a finite population of sequences adapting to NK
fitness landscapes. We find that, unlike in the case of an infinite population, the average …

This work demonstrates how the efficiency of evolutionary algorithms in dynamic
environments can be improved by use of life-time adaptation. Our results contradict the …

NK models provide a family of tunably rugged fitness landscapes used in a wide range of
evolutionary computation studies. It is well known that the average height of local optima …

Evolution and development are related processes although their relationship is still not well
understood. Attempts to explore their relationship are challenged by scales of time and …