Rational evolutionary design: the theory of in vitro protein evolution
Publisher Summary Directed evolution uses a combination of powerful search techniques to
generate proteins with the improved properties. The chapter focuses on controlling the …
generate proteins with the improved properties. The chapter focuses on controlling the …
Dynamic fitness landscapes in molecular evolution
CO Wilke, C Ronnewinkel, T Martinetz - Physics Reports, 2001 - Elsevier
We study self-replicating molecules under externally varying conditions. Changing
conditions such as temperature variations and/or alterations in the environment's resource …
conditions such as temperature variations and/or alterations in the environment's resource …
Biological evolution and statistical physics
B Drossel - Advances in physics, 2001 - Taylor & Francis
This review is an introduction to theoretical models and mathematical calculations for
biological evolution, aimed at physicists. The methods in the field are naturally very similar to …
biological evolution, aimed at physicists. The methods in the field are naturally very similar to …
Generic rugged landscapes under strain and the possibility of rejuvenation in glasses
BA Isner, DJ Lacks - Physical review letters, 2006 - APS
A strain-dependent random landscape model shows that many aspects of the mechanical
response of disordered materials are universal, and arise from the rugged nature of the …
response of disordered materials are universal, and arise from the rugged nature of the …
Universality classes of interaction structures for NK fitness landscapes
Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic
fitness landscapes that aim to capture generic features of epistatic interactions in multilocus …
fitness landscapes that aim to capture generic features of epistatic interactions in multilocus …
[HTML][HTML] Analysis of fitness landscape modifications in evolutionary dynamic optimization
In this work, discrete dynamic optimization problems (DOPs) are theoretically analysed
according to the modifications produced in the fitness landscape during the optimization …
according to the modifications produced in the fitness landscape during the optimization …
Optimal adaptive performance and delocalization in NK fitness landscapes
We investigate the evolutionary dynamics of a finite population of sequences adapting to NK
fitness landscapes. We find that, unlike in the case of an infinite population, the average …
fitness landscapes. We find that, unlike in the case of an infinite population, the average …
On the performance of evolutionary algorithms with life-time adaptation in dynamic fitness landscapes
R Eriksson, B Olsson - Proceedings of the 2004 Congress on …, 2004 - ieeexplore.ieee.org
This work demonstrates how the efficiency of evolutionary algorithms in dynamic
environments can be improved by use of life-time adaptation. Our results contradict the …
environments can be improved by use of life-time adaptation. Our results contradict the …
Maximally rugged NK landscapes contain the highest peaks
NK models provide a family of tunably rugged fitness landscapes used in a wide range of
evolutionary computation studies. It is well known that the average height of local optima …
evolutionary computation studies. It is well known that the average height of local optima …
Evolution of developmental strategies in nk fitness landscapes
Evolution and development are related processes although their relationship is still not well
understood. Attempts to explore their relationship are challenged by scales of time and …
understood. Attempts to explore their relationship are challenged by scales of time and …