Arrhythmogenic cardiomyopathy

D Corrado, C Basso, DP Judge - Circulation research, 2017 - Am Heart Assoc
Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to
sudden cardiac death, particularly in young patients and athletes. Pathological features …

Molecular mechanisms of arrhythmogenic cardiomyopathy

KM Austin, MA Trembley, SF Chandler… - Nature Reviews …, 2019 - nature.com
Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Mechanotransduction in cardiac hypertrophy and failure

RC Lyon, F Zanella, JH Omens, F Sheikh - Circulation research, 2015 - Am Heart Assoc
Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …

'Hot phase'clinical presentation in arrhythmogenic cardiomyopathy

R Bariani, A Cipriani, S Rizzo, R Celeghin… - EP …, 2021 - academic.oup.com
Aims The aim of this study is to evaluate the clinical features of patients affected by
arrhythmogenic cardiomyopathy (AC), presenting with chest pain and myocardial enzyme …

The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes

MS Nielsen, CJM van Opbergen… - Physiological …, 2023 - journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice

YN Lin, T Mesquita, L Sanchez, YH Chen… - European Heart …, 2021 - academic.oup.com
Aims Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of
cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by …

The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease

M Delmar, WJ McKenna - Circulation research, 2010 - Am Heart Assoc
Intercellular communication is essential for proper cardiac function. Mechanical and
electrical activity need to be synchronized so that the work of individual myocytes transforms …

[HTML][HTML] Arrhythmogenic cardiomyopathy

K Pilichou, G Thiene, B Bauce, I Rigato… - Orphanet journal of rare …, 2016 - Springer
Arrhythmogenic cardiomyopathy (AC) is a heart muscle disease clinically characterized by
life-threatening ventricular arrhythmias and pathologically by an acquired and progressive …

Pathophysiology of arrhythmogenic cardiomyopathy

C Basso, B Bauce, D Corrado, G Thiene - Nature Reviews Cardiology, 2012 - nature.com
Arrhythmogenic cardiomyopathy (AC) is a clinically and genetically heterogeneous disorder
of heart muscle that is associated with ventricular arrhythmias and risk of sudden cardiac …

Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report

PM Elliott, A Anastasakis, A Asimaki… - European journal of …, 2019 - Wiley Online Library
It is 35 years since the first description of arrhythmogenic right ventricular cardiomyopathy
(ARVC) and more than 20 years since the first reports establishing desmosomal gene …