Inflammation is a pivotal response to a variety of stimuli, and inflammatory molecules such
as cytokines have central roles in the pathogenesis of various diseases, including bone and …

Objective To highlight the advances over the past year in metabolite/protein biomarkers for
osteoarthritis (OA). Method A literature search of five databases including PubMed, Web of …

Background Many patients report symptomatic relief after undergoing arthroscopy of the
knee for osteoarthritis, but it is unclear how the procedure achieves this result. We …

Background: There are currently no effective disease-modifying drugs to prevent cartilage
loss in osteoarthritis and synovial fluid is a potentially valuable source of biomarkers to …

The history of what, in 1979, was called interleukin-1 (IL-1), orchestrator of leukocyte inter-
communication, began many years before then, initially by the observation of fever induction …

Osteoarthritis (OA) is characterized by cartilage degradation that is induced by inflammation.
Sterile inflammation can be caused by damage-associated molecular patterns that are …

Background: Meniscus tears are classified as traumatic or degenerative based on the tear
pattern. There is little evidence demonstrating biological differences between the 2 tear …

Rhein is an active metabolite of the drug diacerein, whose anti-inflammatory properties have
been demonstrated in both in vitro and in vivo models. However, the low oral bioavailability …

Football is currently the most popular sporting activity in the world. Multiple reports have
shown that a high incidence of osteoarthritis is found in football players. Evidence clearly …

Background Non-steroidal anti-inflammatory drugs are commonly used to reduce pain and
inflammation in orthopaedic patients. Selective cyclooxygenase-2 (COX-2) inhibitors have …