The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The mammary gland develops through several distinct stages. The first transpires in the
embryo as the ectoderm forms a mammary line that resolves into placodes. Regulated by …

The mammary gland is one of the most regenerative organs in the body, with the majority of
development occurring postnatally and in the adult mammal. Formation of the ductal tree is …

Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

The mammary gland undergoes a spectacular series of changes as it develops, and
maintains a remarkable capacity to remodel and regenerate for several decades. Mammary …

Background The development and progression of estrogen receptor alpha positive (ERα+)
breast cancer has been linked epidemiologically to prolactin. However, activation of the …

It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

A cancer cell-centric view has long dominated the field of cancer biology. Research efforts
have focussed on aberrant cancer cell signalling pathways and on changes to cancer cell …

Prolactin coordinates with the ovarian steroids to orchestrate mammary development and
lactation, culminating in nourishment and an increasingly appreciated array of other benefits …

Clinically, circulating prolactin levels and density of the extracellular matrix (ECM) are
individual risk factors for breast cancer. As tumors develop, the surrounding stroma …