Ferroptosis regulation by methylation in cancer

M Hao, Y Jiang, Y Zhang, X Yang, J Han - Biochimica et Biophysica Acta …, 2023 - Elsevier
Epigenetic regulation plays a critical role in cancer development and progression.
Methylation is an important epigenetic modification that influences gene expression by …

[HTML][HTML] Effects of DNA, RNA, and Protein Methylation on the Regulation of Ferroptosis

X Wang, X Kong, X Feng, DS Jiang - International Journal of …, 2023 - ncbi.nlm.nih.gov
Ferroptosis is a form of programmed cell death characterized by elevated intracellular
ferrous ion levels and increased lipid peroxidation. Since its discovery and characterization …

[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer

J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …

Identification of a CD4+ conventional T cells-related lncRNAs signature associated with hepatocellular carcinoma prognosis, therapy, and tumor microenvironment

L Zhu, XP Zhang, S Xu, MG Hu, ZM Zhao… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related
death worldwide, and CD4+ T lymphocytes can inhibit hepatocarcinogenesis and mediate …

[HTML][HTML] Insights into the role of N6-methyladenosine in ferroptosis

J Zhang, T Qiu, X Yao, X Sun - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract N6-methyladenosine (m 6 A) methylation modification is one of the most prevalent
epigenetic modifications of eukaryotic RNA. m 6 A methylation is widely associated with …

Identification of PANoptosis‐Based Prognostic Signature for Predicting Efficacy of Immunotherapy and Chemotherapy in Hepatocellular Carcinoma

X Xiong, Q Song, M Jing, W Yan - Genetics Research, 2023 - Wiley Online Library
Background. PANoptosis has been a research hotspot, but the role of PANoptosis in
hepatocellular carcinoma (HCC) remains widely unknown. Drug resistance and low …

The m6A-related gene signature stratifies poor prognosis patients and characterizes immunosuppressive microenvironment in hepatocellular carcinoma

E Ma, J Li, C Shen, Y Gu, X Zhang, L Li, J Zhao… - Frontiers in …, 2023 - frontiersin.org
Background N6-methyladenosine (m6A) is the most abundant epitranscriptomic modification
of RNA, which can affect RNA metabolism and protein translation. The m6A modification …

Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification

X Sun, H Wang, X Pu, Y Wu, X Yuan, X Wang… - Cancer Gene …, 2024 - nature.com
Abstract N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the
most common epigenetic modification in mammalian mRNA. M6A modifications play a …

METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes

C Zhao, J Li - Journal of Cardiothoracic Surgery, 2024 - Springer
Abstract Background Hypoxia/reoxygenation (H/R) induces cardiomyocyte ferroptosis, a
core remodeling event in myocardial ischemia/reperfusion injury. Methyltransferase-like 14 …

Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

H Chen, Z Han, J Su, X Song, Q Ma, Y Lin… - Frontiers in …, 2024 - frontiersin.org
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a
significant challenge to the medical community because of its high mortality rate. In recent …