Understanding mechanisms of antioxidant action in health and disease

B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …

Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications

CR Powell, KM Dillon, JB Matson - Biochemical pharmacology, 2018 - Elsevier
Hydrogen sulfide (H 2 S) is a ubiquitous small gaseous signaling molecule, playing an
important role in many physiological processes and joining nitric oxide and carbon …

A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

[HTML][HTML] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

[HTML][HTML] Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production

A Longchamp, T Mirabella, A Arduini, MR MacArthur… - Cell, 2018 - cell.com
Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

C Szabo - Biochemical pharmacology, 2018 - Elsevier
The history of H 2 S–as an environmental toxin–dates back to 1700, to the observations of
the Italian physician Bernardino Ramazzini, whose book “De Morbis Artificum Diatriba” …

Simultaneous Sensing of H2S and ATP with a Two-Photon Fluorescent Probe in Alzheimer's Disease: toward Understanding Why H2S Regulates Glutamate …

P Sun, HC Chen, S Lu, J Hai, W Guo, YH Jing… - Analytical …, 2022 - ACS Publications
Energy deprivation and reduced levels of hydrogen sulfide (H2S) in the brain is closely
associated with Alzheimer's disease (AD). However, there is currently no fluorescent probe …