[HTML][HTML] Immune checkpoint Inhibitor–Induced diarrhea and Colitis: Incidence and Management. A systematic review and Meta-analysis

DL Nielsen, CB Juhl, IM Chen, L Kellermann… - Cancer Treatment …, 2022 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) have improved cancer outcomes.
However, immune-related adverse effects are common. The aim was to investigate the …

Joint together: The etiology and pathogenesis of ankylosing spondylitis

Y Xiong, M Cai, Y Xu, P Dong, H Chen, W He… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) refers to a group of diseases with inflammation in joints and spines.
In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the …

Personalized medicine of monoclonal antibodies in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring, and beyond

A Di Paolo, G Luci - Frontiers in Pharmacology, 2021 - frontiersin.org
The pharmacotherapy of inflammatory bowel diseases (Crohn's disease and ulcerative
colitis) has experienced significant progress with the advent of monoclonal antibodies …

MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells

S Vimonpatranon, LR Goes, A Chan, I Licavoli… - PLoS …, 2023 - journals.plos.org
CD4+ tissue resident memory T cells (TRMs) are implicated in the formation of persistent
HIV reservoirs that are established during the very early stages of infection. The tissue …

Targeting immune cell trafficking and vascular endothelial cells in psoriasis

KZ Young, O Plazyo… - The Journal of Clinical …, 2023 - Am Soc Clin Investig
The role of the vasculature in inflammatory skin disorders is an exciting area of investigation.
Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier …

Vedolizumab in the treatment of ulcerative colitis: an evidence-based review of safety, efficacy, and place of therapy

N Takatsu, T Hisabe, D Higashi, T Ueki, T Matsui - Core evidence, 2020 - Taylor & Francis
Introduction: Selective blockade of the integrins and mucosal adhesion molecules is a
promising therapeutic strategy for ulcerative colitis (UC). Vedolizumab (VDZ), a humanized …

[HTML][HTML] MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gutCD101+ TRM phenotype

A Girard, S Vimonpatranon, A Chan, A Jiang… - Mucosal …, 2024 - Elsevier
Resident memory T cells (T RM s) help control local immune homeostasis and contribute to
tissue-protective immune responses. The local cues that guide their differentiation and …

Novel preclinical developments of the primary sclerosing cholangitis treatment landscape

A Sohal, KV Kowdley - Expert Opinion on Investigational Drugs, 2024 - Taylor & Francis
Introduction Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease
associated with inflammation, fibrosis, and destruction of intra-and extrahepatic bile ducts …

Experimental Evaluation of the Impact of Gadolinium Orthovanadate Gdvo4: Eu3% 2B Nanoparticles on the Carrageenan-Induced Intestinal Inflammation

AS Tkachenko, GI Gubina-Vakulyck, VK Klochkov… - ACTA …, 2020 - karolinum.cz
Aim: To evaluate the effects of orally administered gadolinium orthovanadate GdVO4: Eu3+
nanoparticles (VNPs) on the course of chronic carrageenan-induced intestinal inflammation …

Prophylactic Treatment with Vedolizumab in the Prevention of Postoperative Recurrence (POR) in High-Risk Crohn's Patients

G Frieri, M Valvano, S Frassino, S Faenza… - Journal of Clinical …, 2023 - mdpi.com
About 50% of Crohn's Disease (CD) patients undergo an intestinal resection during their
lifetime. Although the patients experience a fairly long period of well-being after the intestinal …