[HTML][HTML] Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

QS Li, YJ Jia - Neural Regeneration Research, 2023 - journals.lww.com
Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-
dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic …

[HTML][HTML] Future perspectives in spinal cord repair: brain as saviour? TSCI with concurrent TBI: pathophysiological interaction and impact on MSC treatment

P Köhli, E Otto, D Jahn, MJ Reisener, J Appelt… - Cells, 2021 - mdpi.com
Traumatic spinal cord injury (TSCI), commonly caused by high energy trauma in young
active patients, is frequently accompanied by traumatic brain injury (TBI). Although …

[HTML][HTML] Metabolic detection of malignant brain gliomas through plasma lipidomic analysis and support vector machine-based machine learning

J Zhou, N Ji, G Wang, Y Zhang, H Song, Y Yuan… - …, 2022 - thelancet.com
Background Most malignant brain gliomas (MBGs) are associated with dismal outcomes,
mainly due to their late diagnosis. Current diagnostic methods for MBGs are based on …

Comparing Brain and Blood Lipidome Changes following Single and Repetitive Mild Traumatic Brain Injury in Rats

AN Pulliam, EC Gier, DA Gaul, SG Moore… - ACS Chemical …, 2024 - ACS Publications
Traumatic brain injury (TBI) is a major health concern in the United States and globally,
contributing to disability and long-term neurological problems. Lipid dysregulation after TBI …

Spatially Resolved Metabolomics Method for Mapping the Global Molecular Landscape of Whole-Body Zebrafish (Danio rerio) Using Ambient Mass Spectrometry …

Y Sun, Z Zhou, B Xie, Z Wang, Z Abliz - Analytical Chemistry, 2023 - ACS Publications
Zebrafish (Danio rerio) represent an effective model biological material for human disease
research, even for personalized precision medicine. Thus, it is necessary to fully …

[HTML][HTML] Lipidome alterations following mild traumatic brain injury in the rat

EC Gier, AN Pulliam, DA Gaul, SG Moore, MC LaPlaca… - Metabolites, 2022 - mdpi.com
Traumatic brain injury (TBI) poses a major health challenge, with tens of millions of new
cases reported globally every year. Brain damage resulting from TBI can vary significantly …

Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness

L Xu, Q Ge, H Lu, Y Zhuang, X Geng, X Chen… - Brain and …, 2023 - Wiley Online Library
Introduction Medical management of disorders of consciousness (DoC) is a growing issue
imposing a major burden on families and societies. Recovery rates vary widely among …

[HTML][HTML] Valproic Acid Treatment after Traumatic Brain Injury in Mice Alleviates Neuronal Death and Inflammation in Association with Increased Plasma …

R Hummel, E Dorochow, S Zander, K Ritter… - Cells, 2024 - mdpi.com
The histone deacetylase inhibitor (HDACi) valproic acid (VPA) has neuroprotective and anti-
inflammatory effects in experimental traumatic brain injury (TBI), which have been partially …

[HTML][HTML] Plasma lipid profiles change with increasing numbers of mild traumatic brain injuries in rats

CC Anyaegbu, H Szemray, SC Hellewell, NG Lawler… - Metabolites, 2022 - mdpi.com
Mild traumatic brain injury (mTBI) causes structural, cellular and biochemical alterations
which are difficult to detect in the brain and may persist chronically following single or …

LC‐MS‐based urine metabolomics analysis of chronic subdural hematoma for biomarker discovery

J Sun, Y Ou, X Liu, H Sun, Z Guo, F Qi… - PROTEOMICS …, 2024 - Wiley Online Library
Background Chronic subdural hematoma (CSDH) is one of the most common neurosurgical
diseases with atypical manifestations. The aim of this study was to utilize urine …