T-cell activation and dysfunction relies on direct and modulated receptors. Based on their
functional outcome, co-signaling molecules can be divided as co-stimulators and co …

Chronic myeloid leukemia (CML) is a hematological cancer, characterized by a reciprocal
chromosomal translocation between chromosomes 9 and 22 [t (9; 22)], producing the Bcr …

Simple Summary Effector immune system cells have the ability to kill tumor cells. However,
as a cancer (such as leukemia) develops, it inhibits and evades the effector immune …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell
immunity plays a critical role in the development of RA. Recently, A20 was identified as a …

Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th)
subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T …

Objective T cell dysfunction is a common characteristic of patients with myeloid leukemia
and is closely related to clinical efficacy and prognosis. In order to clarify the mechanisms …

While chemotherapy and targeted therapy are successful in inducing the remission of
myeloid leukemia as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) …

Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role
in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated …

Background Cell-mediated immunity is often suppressed in patients with hematological
malignancies. Recently, we found that low T cell receptor (TCR)-CD3 signaling was related …

Background and objective T cell-mediated immunity plays an important role in enhancing
antitumor response. This study aimed to investigate the changes in the T-lymphocyte …