Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …

The adult healthy human pancreas has been poorly studied given the lack of indication to
obtain tissue from the pancreas in the absence of disease and rapid postmortem …

Luteolin is a flavone subclass of flavonoids usually available as glycosylated forms in plant
species. The low aqueous solubility or bioavailability of this herbal compound is the …

Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum
improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To …

Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms
of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is …

Introduction Cancer development and progression is a complex process influenced by co-
evolution of the cancer cells and their microenvironment. However, traditional anti-cancer …

Pancreatic ductal adenocarcinoma (PDAC) therapeutic resistance is largely attributed to a
unique tumor microenvironment embedded with an abundance of cancer-associated …

Pancreatic cancer (PC), a gastrointestinal tract malignant tumor, has a poor prognosis due to
early metastasis and limited response to chemotherapy. Therefore, identifying novel …

Abstract Background Cancer-associated fibroblasts (CAFs) play pivotal roles in
chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However, the underlying …