Exosomes and nano-SDF scaffold as a cell-free-based treatment strategy improve traumatic brain injury mechanisms by decreasing oxidative stress …

M Hajinejad, MH Ebrahimzadeh… - Stem Cell Reviews and …, 2023 - Springer
Traumatic brain injury (TBI) causes a variety of complex pathological changes in brain
parenchymal tissue by increasing neuroinflammatory and apoptosis responses. Currently …

Brain damage and patterns of neurovascular disorder after ionizing irradiation. Complications in radiotherapy and radiation combined injury

NV Gorbunov, JG Kiang - Radiation research, 2021 - meridian.allenpress.com
Exposure to ionizing radiation, mechanical trauma, toxic chemicals or infections, or
combinations thereof (ie, combined injury) can induce organic injury to brain tissues, the …

[HTML][HTML] Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury

T Li, W Zhang, E Hu, Z Sun, P Li, Z Yu, X Zhu… - Computational and …, 2021 - Elsevier
Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability
worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential …

Neuroprotective Effects and Metabolomics Study of Protopanaxatriol (PPT) on Cerebral Ischemia/Reperfusion Injury In Vitro and In Vivo

F Wu, S Lai, D Fu, J Liu, C Wang, H Feng, J Liu… - International Journal of …, 2023 - mdpi.com
Stroke, one of the leading causes of disability and death worldwide, is a severe neurological
disease that threatens human life. Protopanaxatriol (PPT), panaxatriol-type saponin …

Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine

DC Fernandes, RL Reis, JM Oliveira - Drug Discovery Today, 2021 - Elsevier
Highlights•Blood-brain barrier models still lack capacity to combine simplicity and
performance.•Neural models are diverse resource-wise but still limited in characterization.• …

Applying hiPSCs and biomaterials towards an understanding and treatment of traumatic brain injury

M Lacalle-Aurioles, C Cassel de Camps… - Frontiers in Cellular …, 2020 - frontiersin.org
Traumatic brain injury (TBI) is the leading cause of disability and mortality in children and
young adults and has a profound impact on the socio-economic wellbeing of patients and …

Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies

L Cui, Y Saeed, H Li, J Yang - Regenerative Medicine, 2022 - Taylor & Francis
Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized
treatment to combat its long-lasting effects. The objective of the present study was to provide …

Recent advances in stem cell therapies to address neuroinflammation, stem cell survival, and the need for rehabilitative therapies to treat traumatic brain injuries

GR Bjorklund, TR Anderson… - International journal of …, 2021 - mdpi.com
Traumatic brain injuries (TBIs) are a significant health problem both in the United States and
worldwide with over 27 million cases being reported globally every year. TBIs can vary …

Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

L Liu, QJ Deng - Neural Regeneration Research, 2022 - journals.lww.com
Extracellular vesicles are composed of fragments of exfoliated plasma membrane,
organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet …

Neutral and charged forms of inubosin B in aqueous solutions at different pH and on the surface of Ag nanoparticles

MF Hamissa, P Niederhafner, H Šestáková… - Journal of Molecular …, 2022 - Elsevier
One of the strategies to combat neurodegenerative diseases such as Alzheimer's and
Parkinson's diseases, or to heal brain injuries is based on the regeneration of neurons …