Type 2 diabetes mellitus is becoming a major health problem associated with excess
morbidity and mortality. As the prevalence of type 2 diabetes is rapidly increasing …

Background Previous research has suggested that thiazide diuretics and beta-blockers may
promote the development of type 2 diabetes mellitus. However, the results of these studies …

An aggressive global approach to screening and to the management of the metabolic
syndrome is recommended to slow the growth of the syndrome throughout the United States …

Objective: To evaluate the influence of indapamide sustained-release (SR) 1.5 mg/day, a
thiazide-related sulfonamide diuretic, on serum levels of lipids (total cholesterol, high …

Objective To compare the effects of a cardioselective beta-blocker (nebivolol) with those of
an angiotensin-converting enzyme inhibitor (enalapril) on parameters of insulin sensitivity …

Objective: To determine whether age, gender, concomitant disease and/or previous or
present antihypertensive medication affect the safety or antihypertensive efficacy of …

Background—Glucose and insulin levels are associated with left ventricular mass (LVM) in
insulin-resistant individuals. Antihypertensive drugs have different effects on glucose and …

The renal protective effect of antihypertensive drugs is linked to 2 mechanisms. First,
reduction in blood pressure (BP) is a fundamental prerequisite common to all …

PREVIEW High blood pressure presents a major threat in patients with either type 1 or type
2 diabetes. It greatly increases the risks for such complications as end-stage renal disease …

Objectives: To compare the antihypertensive efficacy and tolerability of the imidazoline I-
receptor agonist moxonidine, administered as a single daily dose of 0.6 mg, with the …