All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Despite the wide availability of antibiotics, infectious diseases remain a leading cause of
death worldwide 1. In the absence of new therapies, mortality rates due to untreatable …

Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Abstract “Triterpenoids” can be considered natural products derived from the cyclization of
squalene, yielding 3-deoxytriterpenes (hydrocarbons) or 3-hydroxytriterpenes. Triterpenoids …

Many drugs are derived from small molecules produced by microorganisms and plants, so-
called natural products. Natural products have diverse chemical structures, but the …

Covering: up to the end of 2022 Microorganisms are exceptional sources of a wide array of
unique natural products and play a significant role in drug discovery. During the golden era …

Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …