Cancer immunotherapy has gained traction in recent years owing to remarkable tumor
clearance in some patients. Despite the notable success of immune checkpoint blockade …

Abstract Angiopoietin-1 (Ang-1) and Vascular Endothelial Growth Factor (VEGF) are central
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …

The testicular androgen biosynthesis is well understood, however, how cancer cells gauge
dwindling androgen to dexterously initiate its de novo synthesis remained elusive. We …

Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded
by PTPN11), promotes developmental disorders and several malignancies by varying …

Abstract Hormone receptor-positive, HER2-negative advanced breast cancers exhibit high
sensitivity to CDK4/6 inhibitors such as palbociclib. However, most patients inevitably …

The Src family kinases (SFK) plays an important role in multiple signal transduction
pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders …

Protein tyrosine kinases (PTKs) are a large enzyme family that regulates many cellular
processes. The key to their broad role in signaling is their tunable substrate specificity and …

Abstract Purpose of Review Adult stem cells play a pivotal role in the regeneration and
revival of tissues that have been affected by aging or injury. Emerging studies have provided …

Simple Summary Patients with symptomatic Benign Prostatic Hyperplasia (BPH) showed
upregulated gene expression of biological pathways associated with T cell activation and …

Castration-resistant prostate cancer (CRPC) poses a major treatment challenge, because
disease progression occurs despite androgen deprivation therapy (ADT) 1. Overcoming …