Recent progress regarding kaempferol for the treatment of various diseases

JIE Ren, Y Lu, Y Qian, B Chen… - Experimental and …, 2019 - spandidos-publications.com
Kaempferol, also known as kaempferol‑3 or kaempferide, is a flavonoid compound that
naturally occurs in tea, as well as numerous common vegetables and fruits, including beans …

Bone microenvironment and osteosarcoma metastasis

C Yang, Y Tian, F Zhao, Z Chen, P Su, Y Li… - International journal of …, 2020 - mdpi.com
The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to
seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is …

Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy

DM Gianferante, L Mirabello, SA Savage - Nature Reviews …, 2017 - nature.com
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma

L Mirabello, B Zhu, R Koster, E Karlins, M Dean… - JAMA …, 2020 - jamanetwork.com
Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

JA Perry, A Kiezun, P Tonzi… - Proceedings of the …, 2014 - National Acad Sciences
Osteosarcoma is the most common primary bone tumor, yet there have been no substantial
advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by …

Osteosarcoma

DD Moore, HH Luu - Orthopaedic oncology: primary and metastatic tumors …, 2014 - Springer
Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve
other bones in the body. It has a bimodal distribution with peaks in the second decade of life …

Origin and therapies of osteosarcoma

B Moukengue, M Lallier, L Marchandet, M Baud'huin… - Cancers, 2022 - mdpi.com
Simple Summary Osteosarcoma is the most common malignant bone tumor in children, with
a 5-year survival rate ranging from 70% to 20% depending on the aggressiveness of the …

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

BS Moriarity, GM Otto, EP Rahrmann, SK Rathe… - Nature …, 2015 - nature.com
Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …

Glioblastoma stem-like cells: at the root of tumor recurrence and a therapeutic target

M Jackson, F Hassiotou, A Nowak - Carcinogenesis, 2015 - academic.oup.com
Glioblastoma is the most common and most aggressive primary brain malignancy. The
current initial standard of care consists of maximal safe surgical resection followed by radical …

Pathogenesis and current treatment of osteosarcoma: perspectives for future therapies

R Rathore, BA Van Tine - Journal of clinical medicine, 2021 - mdpi.com
Osteosarcoma is the most common primary malignant bone tumor in children and young
adults. The standard-of-care curative treatment for osteosarcoma utilizes doxorubicin …