Parkinson's disease

BR Bloem, MS Okun, C Klein - The Lancet, 2021 - thelancet.com
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

[HTML][HTML] Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency

D Fiorentini, C Cappadone, G Farruggia, C Prata - Nutrients, 2021 - mdpi.com
Magnesium plays an important role in many physiological functions. Habitually low intakes
of magnesium and in general the deficiency of this micronutrient induce changes in …

[HTML][HTML] Global burden of upper respiratory infections in 204 countries and territories, from 1990 to 2019

X Jin, J Ren, R Li, Y Gao, H Zhang, J Li, J Zhang… - …, 2021 - thelancet.com
Abstract Background Upper respiratory infections (URIs) are among the most common
diseases. However, the related burden has not been comprehensively evaluated. Thus, we …

BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging

J Blesa, JA Pineda-Pardo, K Inoue, C Gasca-Salas… - Science …, 2023 - science.org
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus …

Nanozyme‐enabled treatment of cardio‐and cerebrovascular diseases

Y Zhang, W Liu, X Wang, Y Liu, H Wei - Small, 2023 - Wiley Online Library
Cardio‐and cerebrovascular diseases are two major vascular‐related diseases that lead to
death worldwide. Reactive oxygen species (ROS) play a vital role in the occurrence and …

Ginsenoside Rd: A promising natural neuroprotective agent

YY Chen, QP Liu, P An, M Jia, X Luan, JY Tang… - Phytomedicine, 2022 - Elsevier
Background Neurological diseases seriously affect human health, which are arousing wider
attention, and it is a great challenge to discover neuroprotective drugs with minimal side …

Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

E Plazas, DR Muñoz - Pharmacological Research, 2022 - Elsevier
Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

[HTML][HTML] The economic burden of stroke: a systematic review of cost of illness studies

S Strilciuc, DA Grad, C Radu, D Chira… - Journal of medicine …, 2021 - ncbi.nlm.nih.gov
Stroke is one of the leading causes of morbidity and mortality worldwide. As the number of
stroke cases is rising from one year to another, policymakers require data on the amount …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

[HTML][HTML] Current trends in neurodegeneration: Cross talks between oxidative stress, cell death, and inflammation

T Behl, R Makkar, A Sehgal, S Singh… - International Journal of …, 2021 - mdpi.com
The human body is highly complex and comprises a variety of living cells and extracellular
material, which forms tissues, organs, and organ systems. Human cells tend to turn over …