A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

[HTML][HTML] Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Cellular functions of long noncoding RNAs

RW Yao, Y Wang, LL Chen - Nature cell biology, 2019 - nature.com
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis

H Wu, Y Kirita, EL Donnelly… - Journal of the American …, 2019 - journals.lww.com
Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …

[HTML][HTML] Advances in hypoxia-inducible factor biology

H Choudhry, AL Harris - Cell metabolism, 2018 - cell.com
Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

[HTML][HTML] Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation

T Yamazaki, S Souquere, T Chujo, S Kobelke… - Molecular cell, 2018 - cell.com
A class of long noncoding RNAs (lncRNAs) has architectural functions in nuclear body
construction; however, specific RNA domains dictating their architectural functions remain …

[HTML][HTML] Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems

LZ Yang, Y Wang, SQ Li, RW Yao, PF Luan, H Wu… - Molecular cell, 2019 - cell.com
Visualizing the location and dynamics of RNAs in live cells is key to understanding their
function. Here, we identify two endonuclease-deficient, single-component programmable …

Alternative polyadenylation of mRNA precursors

B Tian, JL Manley - Nature reviews Molecular cell biology, 2017 - nature.com
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …