A guide to membraneless organelles and their various roles in gene regulation
T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …
[HTML][HTML] Integrated lncRNA function upon genomic and epigenomic regulation
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …
LNCcation: lncRNA localization and function
MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …
phenomenon that influences numerous cellular processes. This is also evident for the large …
Cellular functions of long noncoding RNAs
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …
are transcribed from the mammalian genome. They are emerging as important regulators in …
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …
proteins (RBPs) have been discovered in recent years, and the interaction between long …
Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis
H Wu, Y Kirita, EL Donnelly… - Journal of the American …, 2019 - journals.lww.com
Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …
[HTML][HTML] Advances in hypoxia-inducible factor biology
H Choudhry, AL Harris - Cell metabolism, 2018 - cell.com
Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
[HTML][HTML] Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation
T Yamazaki, S Souquere, T Chujo, S Kobelke… - Molecular cell, 2018 - cell.com
A class of long noncoding RNAs (lncRNAs) has architectural functions in nuclear body
construction; however, specific RNA domains dictating their architectural functions remain …
construction; however, specific RNA domains dictating their architectural functions remain …
[HTML][HTML] Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems
Visualizing the location and dynamics of RNAs in live cells is key to understanding their
function. Here, we identify two endonuclease-deficient, single-component programmable …
function. Here, we identify two endonuclease-deficient, single-component programmable …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …