This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Background We conducted a systematic review and meta-analysis to assess effects of
selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake …

Background Duloxetine has been used as an adjunct in multimodal analgesia for acute
postoperative pain in clinical studies. This meta‐analysis aims to conclude whether oral …

Objective To evaluate the efficacy and safety of preoperative duloxetine on postoperative
pain management after gynecologic laparoscopic surgeries. Methods A systematic search …

Pain, the most common symptom reported among patients in the primary care setting, is
complex to manage. Opioids are among the most potent analgesics agents for managing …

Background: Recently, opoids are linked with cancer recurrence. Duloxetine hydrochloride
(DH), an anxiolytic may reduce total opoid requirement after cancer surgery. Aims: We …

BackgroundPostoperative pain is one of the problems in which a lack of adequate controls
can cause many complications. Duloxetine is a potent serotonin and norepinephrine …

Methods: After registering the protocol in the international prospective register of systematic
reviews (PROSPERO), databases like PubMed, Ovid, Scopus, Cochrane Library and …

Background Chronic residual pain after total knee arthroplasty (TKA) is one of the
challenges of postoperative pain management. Duloxetine, by controlling neuropathic pain …

Hysterectomy is a widespread surgical intervention in gynecological practice. Open
abdominal hysterectomy is accompanied by a significant algogenic afferent impulse from the …