Aversion refers to feelings of strong dislike or avoidance toward particular stimuli or
situations. Aversion can be caused by pain stimuli and has a long-term negative impact on …

Abstract Background The plant Ainsliaea fragrans Champ.(A. fragrans) named" Xingxiang
Tuerfeng", is a traditional herb with a long history of therapeutic practice in southern China in …

Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful
neuropathy. The biological mechanisms that control ion channels are important for many cell …

Opioids traced back to ancient civilizations, have evolved in their usage for acute and
chronic pain treatment. Their interaction with the endogenous opioidergic system modulates …

The modulation of TRPV1 emerges as a promising strategy for dental pain management.
This study aimed to assess TRPV1 modulation in a human odontoblast-like cell model using …

Background Osteosarcoma (OS), the commonest primary malignant bone tumor, is mainly
seen in children and teenagers. LINC00960, a newly discovered long intergenic non-protein …

Background Pain is alleviated in one of the two common approaches, pharmacological or
non-pharmacological intervention. Using non-pharmacological methods may have …

胸科手术术后疼痛具有普遍性, 预知性, 在胸腔镜的辅助下术式逐渐微创化,
但仍无法避免其因手术, 麻醉刺激经历的术后剧烈疼痛. 疼痛不仅降低患者舒适度 …

Currently, the development of effective analgesic drugs with few side effects remains a great
challenge. Studies have suggested that multi-target drug treatments show high efficacy and …

In the last decade, opioid-related deaths have risen at an alarming rate. Most of these
deaths involved synthetic opioids. Potent synthetic compounds like fentanyl bind tightly to …