Currently, the development of effective analgesic drugs with few side effects remains a great
challenge. Studies have suggested that multi-target drug treatments show high efficacy and …

In the last decade, opioid-related deaths have risen at an alarming rate. Most of these
deaths involved synthetic opioids. Potent synthetic compounds like fentanyl bind tightly to …

Research progress in ion channel mechanism of morphine addiction Page 1 Chin J Clin Res,
April 2024, Vol.37, No.4 Cite as: Chen X, Wang Y, Wei YY. Research progress in ion channel …

Background: Despite significant progress in critical illness pain evaluation and analgesia,
pain in critical illness remains an unsolved topic (Gélinas et al., 2016; Glowacki et al., 2015) …

Pain represents a major symptom in a multitude of medical conditions and can often become
the main negative factor in a patient's low quality of life. The complex issue of pain …