Protein–protein interactions (PPIs) govern all biological processes. Some small molecules
modulate PPIs through induced protein proximity. In particular, molecular glue degraders …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …

RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins,
constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin …

Two decades into the twenty-first century, a confluence of breakthrough technologies
wielded at the molecular level is presenting biologists with unique opportunities to unravel …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis.
One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

The HIV-1 accessory protein Vpu counteracts a host factor that restricts virion release from
infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1 …