Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …

Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …

Brain is a vital organ of the human body which performs very important functions such as
analysis, processing, coordination, and execution of electrical signals. For this purpose, it …

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …

Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …

A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …

The diversity and complexity of the human brain are widely assumed to be encoded within a
constant genome. Somatic gene recombination, which changes germline DNA sequences to …