Understanding cell-type-specific gene regulatory mechanisms from genetic variants to
diseases remains challenging. To address this, we developed a computational pipeline …

Alzheimer's disease (AD) is the primary cause of dementia in the elderly. It remains
incurable and poses a huge socio-economic challenge for developed countries with an …

Alzheimer's disease is one of the most severe neurodegenerative diseases among elderly
people. Different pathogenic factors for Alzheimer's disease have been posited and studied …

The role of the amyloidogenic pathway in the etiology of Alzheimer's disease (AD),
particularly the common sporadic late onset forms of the disease, is controversial. To some …

Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark
of Alzheimer's disease (AD). Aβ peptides are heterogeneous regarding the exact length of …

Introduction The genetic architecture of Alzheimer's disease (AD) is only partially
understood. Methods We conducted an association study for AD using whole sequence data …

Alzheimer's disease (AD) is thought to be caused by accumulation of amyloid-β protein (Aβ),
which is a cleavage product of amyloid precursor protein (APP). Transgenic mice …

Background Alzheimer's disease (AD) is a neurodegenerative disorder associated with
extracellular amyloid-β peptide deposition and progressive neuron loss. Strong evidence …

Recent data suggest that intraneuronal accumulation of metabolites of the amyloid-β-
precursor protein (APP) is neurotoxic. We observed that transgenic mice overexpressing in …

Alzheimer's disease (AD) is one of the most frequently encountered diseases in adults with
progressive loss of memory and behavioral changes. Inspite of there being an intense …