HIV infection often causes neurological symptoms including cognitive and motor
dysfunction, which have been collectively termed HIV/neuroAIDS. Neuropsychological …

Background Alzheimer's disease amyloid-beta peptides (Aβ) are generated via sequential
cleavage of the amyloid precursor protein (APP) by β-secretase (Bace1) and γ-secretase …

The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β
(Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent …

Curcumin exerts a neuroprotective effect on Alzheimer's disease; however, it is not known
whether microRNAs are involved in this protective effect. This study was conducted using …

Alzheimer's disease (AD) continues to be a daunting and costly challenge for research,
medicine, and society. AD pathologies point toward the involvement of metabolic fragments …

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder caused by a
mutation in the dystrophin gene. In addition to muscle pathology, some patients with DMD …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which no curative
treatments, disease modifying strategies or effective symptomatic therapies exist. Current …

Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid
peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested …

Alzheimer's disease is the most common form of dementia that affects about 50 million of
sufferers worldwide. A major role for the initiation and progression of Alzheimer's disease …

Amyloid Precursor Protein (APP) and its cleavage processes have been widely investigated
in the past, in particular in the context of Alzheimer's Disease (AD). Evidence of an increased …