Background This is the first update of a review published in 2009. Sustained moderate to
severe elevations in resting blood pressure leads to a critically important clinical question …

Background Hypertension is a modifiable cardiovascular risk factor. Although it is
established that low‐dose thiazides reduce mortality as well as cardiovascular morbidity, the …

Investigators often design clinical trials without knowing precisely the values of such
necessary parameters as the variances or the event rates in the control group. In order to …

Secondary or acquired causes of hyperlipidemia can provide important clues to an
underlying metabolic disorder or disease to the observant physician. A consideration of …

Background: Little information has been published on the impact of antihypertensive
medications on quality of life in older persons. Particular concern has existed that lowering …

The large cohort of white men (317,871) 35 to 57 years old at initial screening for possible
enrollment into the Multiple Risk Factor Intervention Trial (MRFIT) was examined with regard …

The relation of total plasma cholesterol to the incidence of coronary heart disease (CHD)
was one of the first findings of the Framingham Heart Study. The Framingham data …

Since 1972, the National High Blood Pressure Education Program (NHBPEP) has released
three Joint National Committee reports plus a task force report on the detection, evaluation …

Hypertension is a significant risk factor for heart disease, stroke and other cardiovascular
diseases and an estimated 970 million people worldwide suffer from the disease resulting in …

Uric acid (UA) is the final product of purine catabolism in man, and it is excreted mainly by
the kidneys when renal function is not impaired. Consequently, serum (S) UA increases as a …