Human deaths caused by Gram-negative bacteria keep rising due to the multidrug
resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with …

Extracellular nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been
identified as a type II transmembrane glycoprotein. It plays a crucial role in various biological …

Osteoarthritis (OA) is a chronic joint disease, characterized by degenerative destruction of
articular cartilage. Chondrocytes, the unique cell type in cartilage, mediate the metabolism of …

ABSTRACT Introduction Matrix metalloproteinases (MMPs) are strongly interlinked with the
progression and mechanisms of several life-threatening diseases including cancer. Thus …

Matrix metalloproteinase 13 plays a central role in osteoarthritis (OA), as its overexpression
induces an excessive breakdown of collagen that results in an imbalance between collagen …

This comprehensive review addresses the intricate and multifaceted regulation of peptidase
activity in human health and disease, providing a comprehensive investigation that extends …

Osteoarthritis (OA) is one of the most prevalent joint diseases in aged people and
characterized by articular cartilage degeneration, synovial inflammation, and abnormal bone …

In 2001, the release of the first draft of the human genome marked the beginning of the Big
Data era for biological sciences. Since then, the complexity of datasets generated by …

Background Osteoarthritis (OA) represents a prominent etiology of considerable pain and
disability, and conventional imaging methods lack sensitivity in diagnosing certain types of …

The ADAMs belong to the Adamalysin family of zinc-dependent metalloproteinases. Some
ADAMs, as membrane-bound enzymes, are responsible for the ectodomain shedding of …