Epilepsies are common chronic neurological diseases characterized by recurrent
unprovoked seizures of central origin. The mainstay of treatment involves symptomatic …

Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons
and their axon terminals, and/or alterations in functional inhibition are conspicuous brain …

Epilepsy is a common disabling chronic neurological disorder characterized by an enduring
propensity for the generation of seizures that result from abnormal hypersynchronous firing …

There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …

Intracerebral drug delivery is an experimental approach for the treatment of drug-resistant
epilepsies that allows for pharmacological intervention in targeted brain regions. Previous …

Intracerebral drug delivery is an emerging treatment strategy aiming to manage seizures in
patients with systemic drug-resistant epilepsies. In rat seizure and epilepsy models, the …

Epilepsy is a severe neurological disease affecting more than 70 million people worldwide
that is characterized by unpredictable and abnormal electrical discharges resulting in …

The most researched brain region in epilepsy research is the temporal lobe, and more
specifically, the hippocampus. However, numerous other brain regions play a pivotal role in …

Despite the immense growth of new anti-seizure drugs (ASDs), approximately one-third of
epilepsy patients remain resistant to current treatment options. Advancements in whole …

Cell transplantation based therapy is a promising strategy for treating intractable epilepsies.
Inhibition of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) is a …