Various lines of evidence indicate the presence of progressive pathophysiological
processes occurring within the brains of patients with schizophrenia. By modulating …

The different types of striatal neuron show a range of vulnerabilities to a variety of insults.
This can be clearly seen in Huntington's disease where a well mapped pattern of …

It has been shown previously that the synthetic corticosteroid dexamethasone induces
apoptosis of granule cells in the dentate gyrus and striatopallidal neurons in the …

Brain morphological alterations in schizophrenic patients have led to the
neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive …

Dexamethasone, a synthetic corticosteroid, which can induce a range of mood disorders
including depression and affective psychosis, is toxic to specific hippocampal and striatal …

Both endogenous and exogenous glucocorticoids (GCs) are known to cause apoptosis in a
number of peripheral tissues and in some cases in the CNS. Additionally, GCs can …

Chronic administration of typical neuroleptics is associated with tardive dyskinesia in some
patients. This dyskinetic syndrome has been associated with loss of GABAergic markers in …

Acute and subchronic administration of N‐methyl‐D‐aspartate antagonists to rats in the
early postnatal period has been reported to produce widespread and selectively cortical …

Antipsychotic drugs are divided into two groups: typical and atypical. Recent clinical studies
show atypical antipsychotics have advantages over typical antipsychotics in a wide variety of …

Quetiapine, a new atypical antipsychotic drug, effectively alleviates positive and negative
symptoms, as well as cognitive impairment that may be caused by neurodegeneration, in …