Male infertility is an increasing problem partly due to inherited genetic variations. Mutations
in genes involved in formation of the sperm tail cause motility defects and thus male …

STUDY QUESTION Which genes are confidently linked to human monogenic male
infertility? SUMMARY ANSWER Our systematic literature search and clinical validity …

Non-obstructive azoospermia (NOA) is a severe and frequent cause of male infertility, often
treated by testicular sperm extraction followed by intracytoplasmic sperm injection. The aim …

Multiple changes occur across various endocrine systems as an individual ages. The
understanding of the factors that cause age-related changes and how they should be …

Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Spermatogenesis defects concern millions of men worldwide, yet the vast majority remains
undiagnosed. Here we report men with primary infertility due to multiple morphological …

Infertility affects approximately 15% of the couples wanting to conceive. In 30− 40% of the
cases the aetiology of male infertility remains unknown and is called idiopathic male …

Male infertility is a major health concern. Among its different causes, multiple morphological
abnormalities of the flagella (MMAF) induces asthenozoospermia and is one of the most …

The multiple morphological abnormalities of the flagella (MMAF) phenotype is among the
most severe forms of sperm defects responsible for male infertility. The phenotype is …

STUDY QUESTION Can whole-exome sequencing (WES) of infertile patients identify new
genes responsible for multiple morphological abnormalities of the sperm flagella (MMAF) …