The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately
200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich …

Clinical asthma is very widely assumed to be the net result of excessive inflammation driven
by aberrant T-helper-2 (Th2) immunity that leads to inflamed, remodelled airways and then …

Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …

Inflammation and its timely resolution are critical to ensure effective host defense and
appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation …

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Lipid metabolism plays an important role in many lung functions. Disorders of lipid
metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD) …

Platelets are the chief effector cells in hemostasis and have additional major functions in
inflammation, vascular integrity, and tissue repair. Platelets and the lungs have interrelated …

Retained respiratory tract (RT) secretions, infection, and exuberant inflammatory responses
are core abnormalities in cystic fibrosis (CF) lung disease. Factors contributing to the …

In this article, we review and analyze different modes of exposure to ultrafine particles in
order to assess particle-induced inflammatory responses and the underlying mechanisms in …

To determine the role of matrix metalloproteinase-8 (MMP-8) in acute lung injury (ALI), we
delivered LPS or bleomycin by the intratracheal route to MMP-8−/− mice versus wild-type …