Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week

L Liberale, L Badimon, F Montecucco… - Journal of the American …, 2022 - jacc.org
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …

[HTML][HTML] Exploring the heart–mind connection: unraveling the shared pathways between depression and cardiovascular diseases

J Sobolewska-Nowak, K Wachowska, A Nowak… - Biomedicines, 2023 - mdpi.com
Civilization diseases are defined as non-communicable diseases that affect a large part of
the population. Examples of such diseases are depression and cardiovascular disease …

[HTML][HTML] Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis

X Liu, M Li, Z Chen, Y Yu, H Shi, Y Yu, Y Wang… - Basic Research in …, 2022 - Springer
Abstract Treatment options for myocarditis are currently limited. Inhibition of calpains has
been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the …

INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10

W Zhang, J Zhao, L Deng, N Ishimwe, J Pauli, W Wu… - Circulation, 2023 - Am Heart Assoc
Background: Activation of vascular smooth muscle cell (VSMC) inflammation is vital to
initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC …

[HTML][HTML] Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products

X Wu, J Wei, Y Yi, Q Gong, J Gao - Frontiers in Pharmacology, 2022 - frontiersin.org
Cardiovascular diseases (CVD) are a group of cardiac and vascular disorders including
myocardial ischemia, congenital heart disease, heart failure, hypertension, atherosclerosis …

[HTML][HTML] Association between high-sensitivity C-reactive protein, functional disability, and stroke recurrence in patients with acute ischaemic stroke: A mediation …

HQ Gu, KX Yang, JX Lin, J Jing, XQ Zhao, YL Wang… - …, 2022 - thelancet.com
Background Post-stroke inflammation biomarker high-sensitivity C-reactive protein (hsCRP)
increases cerebral infarct size and results in functional disability directly, it also contributes …

[HTML][HTML] Inflammatory biomarkers of ischemic stroke

A Tirandi, C Sgura, F Carbone, F Montecucco… - Internal and Emergency …, 2023 - Springer
Ischemic stroke remains the second leading cause of death and among the major causes of
morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies …

[HTML][HTML] Modern concepts in cardiovascular disease: inflamm-aging

YM Puspitasari, S Ministrini, L Schwarz… - Frontiers in cell and …, 2022 - frontiersin.org
The improvements in healthcare services and quality of life result in a longer life expectancy
and a higher number of aged individuals, who are inevitably affected by age-associated …

[HTML][HTML] Chinese herbal injection for cardio-cerebrovascular disease: overview and challenges

J Huajuan, H Xulong, X Bin, W Yue… - Frontiers in …, 2023 - frontiersin.org
Cardio-cerebrovascular diseases are the leading cause of death worldwide and there is
currently no optimal treatment plan. Chinese herbal medicine injection (CHI) is obtained by …

[HTML][HTML] Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model

FJG Waleczek, M Sansonetti, K Xiao, M Jung… - Basic Research in …, 2022 - Springer
Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in the
heart. Plasticity and activation are hallmarks of rcMACs in response to changes in the …