As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The spatial organization of the genome into compartments and topologically associated
domains can have an important role in the regulation of gene expression. But could gene …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …

Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …

Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT)
gene. The mechanism (s) by which mutant HTT (mHTT) causes disease is unclear …

Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features,
yet the molecular composition of the vast majority of CREs in chromatin remains unknown …

The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …