Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …

T follicular helper (Tfh) cells with the phenotype of mainly expressing surface molecules
CXC motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting …

T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities.
Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this …

Ferroptosis, a novel type of regulated cell death mediated by iron-dependent lipid oxidation,
was discovered a decade ago. Significant progress has been made in our knowledge of …

Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Highlights•Immunometabolism dysregulations in lupus have multifactorial
origins.•Contributing factors include genetics and chronic autoantigen stimulation.• …

Given the self-evident importance of cutaneous immunity in the maintenance of body-
surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with …

Ferroptosis was first proposed in 2012, a new form of cell death. Autophagy plays a crucial
role in cell clearance and maintaining homeostasis. Autophagy is involved in the initial step …

Ferroptosis, a newly characterized form of programmed cell death that results from lipid
peroxidation and mitochondrial dysfunction, has been demonstrated to be involved in the …

Background Tissue repair and regeneration in the gastrointestinal system are crucial for
maintaining homeostasis, with the process relying on intricate cellular interactions and …