Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …

Chromosomal phase separation is involved in a broad spectrum of chromosome
organization and functional processes. Nonetheless, the intricacy of this process has left its …

Highlights•Both Polycomb and constitutive heterochromatin components undergo phase
separation.•HP1 drives the formation of condensed structures that contribute to silencing …

Phase separated domains (PSDs) are ubiquitous in cell biology, representing nanoregions
of high molecular concentration. PSDs appear at diverse cellular domains, such as neuronal …

Nucleoli are surrounded by pericentromeric heterochromatin (PCH), reflecting a close
spatial association between the two largest biomolecular condensates in eukaryotic nuclei …

The network structure of densely packed chromatin within the nucleus of eukaryotic cells
acts in concert with nonequilibrium processes. Using statistical physics simulations, we …

Hepatitis B e antigen (HBeAg) seropositivity during the natural history of chronic hepatitis B
(CHB) is known to coincide with significant increases in serum and intrahepatic HBV DNA …

Lamina-associated domains (LADs) are megabase-sized genomic regions that interact with
the nuclear lamina (NL). It is not yet understood how their interactions with the NL are …

The three-dimensional organization of chromatin is influenced by DNA-binding proteins,
through specific and non-specific interactions. However, the role of DNA sequence and …

The review analyzes the role of physicochemical processes in the formation of the function-
dependent architecture of the cell nucleus, built on the platform of a folded genome. The …