Current choices of antibiotic treatment for Pseudomonas aeruginosa infections

D Ibrahim, JF Jabbour, SS Kanj - Current Opinion in Infectious …, 2020 - journals.lww.com
Factors that guide clinical decisions for empiric and directed P. aeruginosa therapy include
the epidemiology, the patient's risk factors, the site of infection, and the available treatment …

[HTML][HTML] Non-CF bronchiectasis: orphan disease no longer

JS Imam, AG Duarte - Respiratory medicine, 2020 - Elsevier
Bronchiectasis is a complex, chronic respiratory condition, characterized by frequent cough
and exertional dyspnea due to a range of conditions that include inherited mucociliary …

Liposomal drug delivery to manage nontuberculous mycobacterial pulmonary disease and other chronic lung infections

JD Chalmers, J van Ingen… - European …, 2021 - Eur Respiratory Soc
Nontuberculous mycobacterial (NTM) pulmonary disease is a chronic respiratory infection
associated with declining lung function, radiological deterioration and significantly increased …

Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models

CL Tan, Y Chan, M Candasamy, J Chellian… - European journal of …, 2022 - Elsevier
Chronic respiratory diseases have collectively become a major public health concern and
have now taken form as one of the leading causes of mortality worldwide. Most chronic …

[HTML][HTML] Preclinical development of orally inhaled drugs (OIDs)—are animal models predictive or shall we move towards in vitro non-animal models?

D Movia, A Prina-Mello - Animals, 2020 - mdpi.com
Simple Summary This commentary focuses on the methods currently available to test the
efficacy and safety of new orally inhaled drugs for the treatment of uncurable respiratory …

An evaluation of inhaled antibiotic liposome versus antibiotic nanoplex in controlling infection in bronchiectasis

TT Tran, H Yu, C Vidaillac, AYH Lim… - International journal of …, 2019 - Elsevier
Inhaled antibiotic nanoparticles have emerged as an effective strategy to control infection in
bronchiectasis lung owed to their mucus-penetrating ability. Using ciprofloxacin (CIP) as the …

Micro/nanosystems and biomaterials for controlled delivery of antimicrobial and anti-biofilm agents

A Bianchera, F Buttini, R Bettini - Expert Opinion on Therapeutic …, 2020 - Taylor & Francis
Introduction Microbial resistance is a severe problem for clinical practice due to misuse of
antibiotics that promotes the development of surviving strategies by bacteria and fungi …

[HTML][HTML] Antimicrobial resistance in common respiratory pathogens of chronic bronchiectasis patients: a literature review

R Inchingolo, C Pierandrei, G Montemurro… - Antibiotics, 2021 - mdpi.com
Non-cystic fibrosis bronchiectasis is a chronic disorder in which immune system
dysregulation and impaired airway clearance cause mucus accumulation and consequent …

[HTML][HTML] The Respiratory Microbiome in Paediatric Chronic Wet Cough: What Is Known and Future Directions

B Atto, Y Anteneh, S Bialasiewicz, MJ Binks… - Journal of Clinical …, 2023 - mdpi.com
Chronic wet cough for longer than 4 weeks is a hallmark of chronic suppurative lung
diseases (CSLD), including protracted bacterial bronchitis (PBB), and bronchiectasis in …

Management of chronic Pseudomonas aeruginosa infection with inhaled levofloxacin in people with cystic fibrosis

JS Elborn, PA Flume, DR Van Devanter… - Future …, 2021 - Taylor & Francis
People with cystic fibrosis (CF) are highly susceptible to bacterial infections of the airways.
By adulthood, chronic Pseudomonas aeruginosa (Pa) is the most prevalent infective …