[HTML][HTML] Drugging the efferocytosis process: concepts and opportunities
P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
[HTML][HTML] Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …
environment or partition cells into distinct compartments. These membranes are lipid …
[HTML][HTML] Macrophages: the good, the bad, and the gluttony
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …
sterile inflammation. In this review, we will compile and interpret recent findings on the …
[HTML][HTML] Phagocytosis: our current understanding of a universal biological process
E Uribe-Querol, C Rosales - Frontiers in immunology, 2020 - frontiersin.org
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …
in diameter, including microorganisms, foreign substances, and apoptotic cells …
The clearance of dead cells by efferocytosis
E Boada-Romero, J Martinez, BL Heckmann… - … reviews Molecular cell …, 2020 - nature.com
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …
induced in a setting-dependent manner. As billions of cells die during mammalian …
Efferocytosis in health and disease
AC Doran, A Yurdagul Jr, I Tabas - Nature Reviews Immunology, 2020 - nature.com
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …
[HTML][HTML] A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication
Extracellular vesicles (EVs) are small, membrane-bound structures that are released from
cells into the surrounding environment. These structures can be categorized as exosomes …
cells into the surrounding environment. These structures can be categorized as exosomes …
A journey from structure to function of bacterial lipopolysaccharides
F Di Lorenzo, KA Duda, R Lanzetta, A Silipo… - Chemical …, 2021 - ACS Publications
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …
negative bacteria, playing a fundamental role in the protection of bacteria from …
[HTML][HTML] Towards an understanding of synapse formation
TC Südhof - Neuron, 2018 - cell.com
Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
N Scott‐Hewitt, F Perrucci, R Morini, M Erreni… - The EMBO …, 2020 - embopress.org
Neuronal circuit assembly requires the fine balance between synapse formation and
elimination. Microglia, through the elimination of supernumerary synapses, have an …
elimination. Microglia, through the elimination of supernumerary synapses, have an …