In many photosynthetic organisms, tight-binding Rubisco inhibitors are released by the
motor protein Rubisco activase (Rca). In higher plants, Rca plays a pivotal role in regulating …

The 26S proteasome is a 2.5 MDa molecular machine for the degradation of substrates of
the ubiquitin-proteasome pathway with a key role in cellular proteostasis. Until recently, only …

The p97/VCP ATPase complex facilitates the extraction and degradation of ubiquitinated
proteins from larger structures. We therefore studied if p97 participates to the rapid …

In accordance with the second law of thermodynamics, in living organisms, energy produced
by ATP hydrolysis was believed to be exclusively required for biosynthetic reactions, but not …

The 26S proteasome is an ATP-dependent dynamic 2.5 MDa protease that regulates
numerous essential cellular functions through degradation of ubiquitinated substrates. Here …

The AAA+ (ATPases associated with a variety of cellular activities) enzymes play critical
roles in a variety of homeostatic processes in all kingdoms of life. Valosin-containing protein …

The proteasomal ATPase ring, comprising Rpt1–Rpt6, associates with the heptameric α-ring
of the proteasome core particle (CP) in the mature proteasome, with the Rpt carboxy …

The primary functions of the proteasome are driven by a highly allosteric ATPase complex.
ATP binding to only two subunits in this hexameric complex triggers substrate binding …

Hexameric ATP-dependent proteases and protein remodeling machines use conserved
loops that line the axial pore to apply force to substrates during the mechanical processes of …

ATP-dependent proteases maintain protein quality control and regulate diverse intracellular
functions. Proteasomes are primarily responsible for these tasks in the archaeal and …