Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

Neuropathic pain (NPP) is a common syndrome associated with most forms of cancer, which
poses a serious threat to human health. NPP may persist even after the nociceptive …

Migraine is a complicated neurological disorder affecting 6% of men and 18% of women
worldwide. Various mechanisms, including neuroinflammation, oxidative stress, altered …

Paclitaxel (PTX) is an anti-microtubule agent, used for the treatment of various types of
cancers; however, it produces painful neuropathy which limits its use. Many neuroprotective …

Primary sensory neurons regulate inflammatory processes in innervated regions through
neuro-immune communication. However, how their immune-modulating functions are …

Traumatic peripheral neuropathic pain is a complex syndrome caused by a primary lesion or
dysfunction of the peripheral nervous system. Secondary to the lesion, resident or infiltrating …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …