Osteoarthritis (OA) is one of the most common joint disorder, with pain accompanied by
functional impairment, as the most pronounced clinical symptom. Currently used …

Background Sciatica (neuropathic pain [NP]) is a common disease characterized by pain
from radiation along the sciatic nerve. The aim of this study was to study the genes …

Background: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory
diseases with shared genetic backgrounds and clinical comorbidities. Headache, a common …

Nerve injury induced microglia activation, which released inflammatory mediators and
developed neuropathic pain. Picroside Ⅱ (PⅡ) attenuated neuropathic pain by inhibiting …

Inflammation during the perioperative period of joint arthroplasty is a critical aspect of patient
outcomes, influencing both the pathophysiology of pain and the healing process. This …

Objective To explore the differential expression of genes between wild-type chronic
compressive injury (CCI) mice (WT-CCI) and interferon regulatory factors 4 (IRF4) knockout …

目的三叉神经痛(trigeminal neuralgia， TN) 是一种严重的慢性神经病理性疼痛，
主要影响三叉神经分布区域， 临床治疗效果不佳。 TN 的治疗方法众多， 但目前临床上主要是 …

Introduction: The neuromodulating effects of transcutaneous-spinal Direct Current
Stimulation (tsDCS) have been reported to block pain signaling. For patients with chronic …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

Background: Chronic postsurgical inguinal pain (CPIP) is the most common complication of
groin hernia surgery. The characteristics of patients, their medical care, and choice of the …