Background Patients with major depression respond to antidepressant treatment, but 10%–
30% of them do not improve or show a partial response coupled with functional impairment …

BACKGROUND: Increasing dissatisfaction with the non-specificity of major depression has
led many to propose more specific depressive subtyping models. The present meta-review …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

The drug efflux pump P‐glycoprotein (P‐gp) plays an important role in the function of the
blood–brain barrier by selectively extruding certain endogenous and exogenous molecules …

There is a strong medical need to develop suitable biomarkers to improve the diagnosis and
treatment of depression, particularly in predicting response to certain therapeutic …

There is considerable diversity in how treatment-resistant depression (TRD) is defined.
However, every definition incorporates the concept that patients with TRD have not …

Background Major depressive disorder is a common, recurrent, disabling and costly disorder
that is often severe and/or chronic, and for which non-remission on guideline concordant first …

Many patients with depression fail to derive sufficient benefit from available treatment
options, with up to a third never reaching remission despite multiple trials of appropriate …

Context Treatment Resistant Depression (TRD) is a significant and burdensome health
concern. Objective To characterize, compare and understand the difference between TRD …