The closed-head impact model of engineered rotational acceleration (CHIMERA) as an application for traumatic brain injury pre-clinical research: a status report

EH McNamara, AA Grillakis, LB Tucker… - Experimental neurology, 2020 - Elsevier
Closed-head traumatic brain injury (TBI) is a worldwide concern with increasing prevalence
and cost to society. Rotational acceleration is a primary mechanism in TBI that results from …

Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?

D Lerouet, C Marchand‐Leroux… - Fundamental & clinical …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) constitutes a major health problem worldwide and is a leading
cause of death and disability in individuals, contributing to devastating socioeconomic …

Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury

P Wei, K Wang, C Luo, Y Huang, D Misilimu… - Journal of …, 2021 - Springer
Background The secondary injury caused by traumatic brain injury (TBI), especially white
matter injury (WMI), is highly sensitive to neuroinflammation, which further leads to …

The benefits of exercise for outcome improvement following traumatic brain injury: Evidence, pitfalls and future perspectives

Y Zhang, Z Huang, H Xia, J Xiong, X Ma, C Liu - Experimental Neurology, 2022 - Elsevier
Traumatic brain injury (TBI), also known as a silent epidemic, is currently a substantial public
health problem worldwide. Given the increased energy demands following brain injury …

[HTML][HTML] Sex specific effects of buprenorphine on behavior, astrocytic opioid receptor expression and neuroinflammation after pediatric traumatic brain injury in mice

Y Hamood, M Abdullah, H El Ghoul, N Saad… - Brain, Behavior, & …, 2022 - Elsevier
Children who suffered traumatic brain injury (TBI) often experience acute and chronic pain,
which is linked to a poor quality of life. Buprenorphine (BPN) is commonly used to treat …

The therapeutic potential and limitations of ketones in traumatic brain injury

SA Daines - Frontiers in neurology, 2021 - frontiersin.org
Traumatic brain injury (TBI) represents a significant health crisis. To date, no FDA approved
pharmacotherapies are available to prevent the neurological deficits caused by TBI. As an …

Genetic diversity drives extreme responses to traumatic brain injury and post-traumatic epilepsy

T Shannon, C Cotter, J Fitzgerald, S Houle… - Experimental …, 2024 - Elsevier
Traumatic brain injury (TBI) is a complex and heterogeneous condition that can cause wide-
spectral neurological sequelae such as behavioral deficits, sleep abnormalities, and post …

Raloxifene modulates microglia and rescues visual deficits and pathology after impact traumatic brain injury

MG Honig, NA Del Mar, DL Henderson… - Frontiers in …, 2021 - frontiersin.org
Mild traumatic brain injury (TBI) involves widespread axonal injury and activation of
microglia, which initiates secondary processes that worsen the TBI outcome. The …

Lipidome alterations following mild traumatic brain injury in the rat

EC Gier, AN Pulliam, DA Gaul, SG Moore, MC LaPlaca… - Metabolites, 2022 - mdpi.com
Traumatic brain injury (TBI) poses a major health challenge, with tens of millions of new
cases reported globally every year. Brain damage resulting from TBI can vary significantly …

Immune-endocrine interactions in the pathophysiology of sleep-wake disturbances following traumatic brain injury: A narrative review

RK Rowe, GS Griesbach - Brain Research Bulletin, 2022 - Elsevier
Following a traumatic brain injury (TBI), sleep-wake disturbances are one of the most
prevalent and debilitating symptoms. A better understanding of the impact that sleep …