Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR that is expressed in the
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …

Dopamine receptors are widely distributed in the central nervous system and are important
therapeutic targets for treatment of various psychiatric and neurological diseases. Here, we …

Abstract Dopamine D1 receptor (D1R) is an important drug target implicated in many
psychiatric and neurological disorders. Selective agonism of D1R are sought to be the …

The dopamine D1 receptor (D1R), is a class AG protein coupled-receptor (GPCR) which has
been a promising drug target for psychiatric and neurological disorders such as Parkinson's …

The dopamine D1 receptor (D1R) is essential for neurotransmission in various brain
pathways where it modulates key functions including voluntary movement, memory …

Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic
opportunities for treating Parkinson's Disease (PD) motor and cognitive deficits. Biased D1 …

Therapies for psychiatric and neurological disorders have been in the development and
refinement process for the past 5 decades. Yet, most of these therapies lack optimal …

The growing size of make-on-demand chemical libraries is posing new challenges to
cheminformatics. These ultra-large chemical libraries became too large for exhaustive …

Dopamine regulates normal functions such as movement, reinforcement learning, and
cognition, and its dysfunction has been implicated in multiple psychiatric and neurological …